B-hCTLA4/h4-1BB mice

C57BL/6-Ctla4tm1(CTLA4)Bcgen Cd137tm1(CD137)Bcgen/Bcgen • 120539

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B-hCTLA4/h4-1BB mice

Catalog Number: 120539
Strain Name: C57BL/6-Ctla4tm1(CTLA4)Bcgen Cd137tm1(CD137)Bcgen/Bcgen
Strain Background: C57BL/6
NCBI gene ID: 3604,1493 (Human)
Aliases: ILA; 4-1BB; CD137; CDw137; IMD109; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
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B-hCTLA4/h4-1BB mice

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  • Phenotypic analysis

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      Protein expression analysis

      Strain specific CTLA4 and 4-1BB expression analysis in homozygous B-hCTLA4/h4-1BB mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hCTLA4/h4-1BB (H/H) mice stimulated with anti-CD3ε in vivo and analyzed by flow cytometry using species-specific anti-hCTLA4 and anti-h4-1BB antibodies. Mouse CTLA4 and 4-1BB were detectable in WT mice but not in homozygous B-hCTLA4/h4-1BB mice. Human CTLA4 and 4-1BB were exclusively detectable in homozygous B-hCTLA4/h4-1BB mice but not in WT mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hCTLA4/h4-1BB mice] (Cat# 120539) was purchased from Biocytogen.