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Ser46 phosphorylation of p53 is an essential event in prolyl-isomerase Pin1-mediated p53-independent apoptosis in response to heat stress

Heat stroke has increased in frequency worldwide in recent years and continues to have a high morbidity and mortality. Identification of the mechanisms mediating heat stoke is important and necessary. Our preliminary study revealed heat stress (HS)-induce

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Webinar: Antibody Discovery Platforms and RenMab Mouse

Biocytogen Chief Scientific Officer and Head of Drug Discovery, Benny Yang PhD. will speak on the current landscape of antibody discovery platforms, with special focus on fully human antibody mice.

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Novel CTLA-4 Antibodies of Potent Antitumor Activity Were Verified in Humanized Mouse Models

CTLA-4 is a member of the immunoglobulin superfamily, and is homologous to the co-stimulatory protein CD28, and both receptors bind to the same ligands, CD80(B7-1) and CD86(B7-2).

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Evaluating Anti-PD-1/CD40 In Vivo Efficacy and Safety on Humanized Double Knock-in Mice

Over the past years, monoclonal antibodies have been successfully utilized in clinical trials to block or active key mediators of immune checkpoint pathways. However, along the IO drug development process,

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Biocytogen’s In Vivo Drug Screening Platform Accelerated 4-1BB Agonistic Antibody Development

4-1BB (TNFRSF9/CD137) belongs to the TNFR superfamily. 4-1BB is expressed by activated CD4 helper T cells, B cells, natural killer cells, natural killer T cells, dendritic cells, and activated endothelium.

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Rapid Screening of Anti-OX40 Antibodies for Cancer Immunotherapy

OX40 is a co-stimulatory receptor, and it interacts with its ligand to provide positive signal for T cell activation. Disruption of the OX40 pathway led to defective T cell responses and overexpression of OX40 caused massive immune activation.

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RenMab™ Mouse Platform Drives SARS CoV-2 Neutralizing Antibody Cocktail Therapy Towards Clinical Trials in Biocytogen and Eucure Biopharma Partnership

[MA, USA and Beijing, China – August] The COVID-19 pandemic has been an inescapable, lethal, and overwhelming aspect of daily human life, threatening health and safety on a global scale. Biocytogen is excited to announce a breakthrough in scientific rese

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Novel hCD3e Mouse Models for Preclinical Pharmacology Study of Therapeutic Bispecific Antibody

CD3e is one of four subunits of the CD3 co-receptor, which plays an important role in the immune response, associating with the T cell receptor (TCR) to couple antigen recognition to intracellular signal transduction, leading to T cell activation.

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PEGS Europe 2019

Biocytogen has recently developed RenMab™ Mouse, a fully human antibody mouse with its entire variable regions replaced by human Ig heavy chain and light chain.

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Anti-SIRPα Antibodies as A Potential Weapon for Cancer Immunotherapy via Accelerated Screening in Humanized Mouse Models

Signal regulatory protein α (SIRPα) is a transmembrane protein and is especially abundant in myeloid cells such as macrophages and DCs, whereas it is expressed at very low levels in T, B and NK cells.

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