CAR-T 세포치료제약효연구를위한면역결핍마우스

B-NDG 마우스에서 CAR-T 세포 치료제 효능 평가 예시

Case 1: B-NDG와 B-NDG 시리즈에서 CAR-T 세포 치료제가 인간 B 세포 림프종에 끼치는 영향

Raji-Luc cells were implanted intravenously into B-NDG mice on Day 0. CAR-T cells were also intravenously injected at the time of Raji-Luc implantation. (A) Luciferase signal intensity of CAR-T cell treatment; (B) Body weight of treated B-NDG mice.

Case 2: B-NDG B2M KO 마우스에서 CAR-T 세포 치료제가 인간 B 세포 림프종에 끼치는 영향

(A) Survival rate of B-NDG mice (n=5) and B-NDG B2M mice (n=9) after PMBC reconstitution and Car-T therapy. (B)Total flux in B-NDG B2M KO mice treated with CAR-T1 or CAR-T2 cells. (C) Density of CAR-T cells in B-NDG B2M KO mice. These results demonstrated that CAR-T cells were amplified first to kill tumor cells, and then reduced as tumor cells were eliminated.

Back to top
카카오톡 상담하기