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RenNano: Fully Human Nanobody Mice Platform


Fully human heavy chain variable region and modified constant region



Robust immune response compared with RenMab mouse


Diversity of the antigen-specific antibodies discovered from RenNano


High binding affinity at nanomolar range


Good developability




Poster


AACR 2023: RenNano® Mice: A Heavy-Chain-Only Antibody Platform for the Generation of Nanobody Therapeutics