B-hCCL4 mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen, drug development, antibody discovery

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동물/세포 모델

동물/세포모델

Humanized Mouse Models

Cytokine Humanized Mice

Text

B-hCCL4 mice

Strain Name

C57BL/6JNifdc-Ccl4^{tm1(CCL4)Bcgen}/Bcgen

Common Name

B-hCCL4 mice

Background

C57BL/6JNifdc

Catalog number

111440

Aliases

CCL4: ACT2, AT744.1, G-26, HC21, LAG-1,

LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4

Protein expression analysis

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Strain specific CCL4 expression analysis in homozygous B-hCCL4 mice by ELISA. Serum were isolated from wild-type C57BL/6J mice (+/+) and homozygous B-hCCL4 mice (H/H) and stimulated with 1 mg/mL LPS in vivo for 24 h and analyzed by ELISA with species-specific CCL4 ELISA kit. Mouse CCL4 was detectable in wild-type mice (A). Human CCL4 was exclusively detectable in homozygous B-hCCL4 mice but not in wild-type mice (B).