Gene description

IL4R (interleukin 4 receptor) This gene encodes the alpha chain of the IL4 receptor and belongs to the type I transmembrane protein, which plays a huge role in the immune response. IL4R can bind to IL4 and IL13 to regulate the production of IgE, and binding to IL4 can promote the differentiation of Th2 cells, thereby inducing the occurrence of asthma.Antagonists of IL4 and IL4R can reduce the level of IL4 in the body, and can exert anti-inflammatory and anti-immune effects on asthma patients. IL4 and IL4R are considered to be star targets for the treatment of allergies and asthma.

Protein expression analysis

Strain specific IL4RA expression analysis in homozygous B-hIL4RA mice by flow cytometry.Splenocytes were collected from WT and homozygous B-hIL4RA (H/H) mice stimulated with or without anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-IL4RA antibody. Mouse Il4ra was detectable in WT mice. Human IL4RA was exclusively detectable in homozygous B-hIL4RA mice but not WT mice.