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B-hVEGFR1 mice
Strain Name
 C57BL/6-Flt1tm1(FLT1)Bcgen/Bcgen  
Common Name  B-hIGF1R mice
Background C57BL/6 Catalog number 110981
Aliases  FLT1 (FLT; FLT-1; VEGFR1; VEGFR-1)
mRNA and Protein expression analysis

from clipboard


Strain specific analysis of VEGFR1 gene expression in wild-type mice and B-hVEGFR1 mice by RT-PCR. Mouse VEGFR1 mRNA was detectable in lung of wild-type mice (+/+). Human VEGFR1 mRNA was detectable only in homozygous B-hVEGFR1 mice (H/H) but not in wild-type mice.

Strain specific VEGFR1 expression analysis in homozygous B-hVEGFR1 mice by flow cytometry. Pulmonary vascular endothelial cells were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hVEGFR1 mice (H/H), and analyzed by flow cytometry with anti-VEGFR1 antibody. Human VEGFR1 was exclusively detectable in homozygous B-hVEGFR1 mice but not in wild-type mice. Mouse VEGFR1 was detectable in wild type mice and homozygous B-hVEGFR1 mice, as the antibody is crossly reactive with VEGFR1 in human and mice.