B-hCD155 mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen, drug development, antibody discovery

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동물/세포 모델

동물/세포모델

Humanized Mouse Models

Humanizad Mouse Models

Text

B-hCD155 mice

Strain Name	C57BL/6-Cd155^{tm1(CD155)Bcgen}/Bcgen	Common Name	B-hCD155 mice
Background	C57BL/6	Catalog number	110759
Related Genes	PVR, HVED, NECL5, Necl-5, PVS, TAGE4
NCBI Gene ID	52118

mRNA expression analysis

Strain specific analysis of CD155 gene expression in wild type (WT) and B-Hcd155 mice by RT-PCR.

Mouse Cd155 mRNA was detectable only in splenocytes of wild type (+/+) mice. Human CD155 mRNA was detectable only in homozygous B-hCD155 but not in wild-type mice.

Protein expression analysis

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Strain specific CD155 expression analysis in homozygous B-hCD155 mice by flow cytometry.

Peritoneal washing macrophage were collected from wild-type (+/+) and homozygous B-hCD155 (H/H) mice and analyzed by flow cytometry with species-specific anti-CD155 antibody. Mouse CD155 was detectable in wild-type mice. Human CD155 was exclusively detectable in homozygous B-hCD155 but not in wild-type mice.

The expression of CD155 in tissues of B-hCD155 mice (female)

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The expression of CD155 in tissues of B-hCD155 mice. Different levels of hCD155 positive signals can be detected in the heart, liver, spleen, lung, kidney, pancreas, thymus, salivary gland, duodenum, jejunum, ileum, colon, ovary, lymph node, bladder and brain of B-hCD155 mice. Positive control: NUGC4; Negative control: C57BL/6 wild-type mice.

The symbol in the upper left corner represents signal strength (-~+++). No positive staining (-), suspicious positivity (±), weakly positive (+), moderately positive (++), and strongly positive (+++).

The expression of CD155 in tissues of B-hCD155 mice (male)

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The expression of CD155 in tissues of B-hCD155 mice. Different levels of hCD155 positive signals can be detected in the heart, liver, spleen, lung, kidney, pancreas, thymus, salivary gland, duodenum, jejunum, ileum, colon, prostate gland, lymph node, bladder, testis and brain of B-hCD155 mice. Positive control: NUGC4; Negative control: C57BL/6 wild-type mice.

The expression of CD155 in tissues of human

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The expression of CD155 in tissues of human. Different levels of hCD155 positive signals can be detected in the heart, liver, spleen, lung, kidney, pancreas, thymus, salivary gland, colon, ovary, prostate gland, testis, lymph node, bladder and brain of human.