B-hCD94/hNKG2A/hNKG2C mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen, drug development, antibody discovery

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동물/세포 모델

동물/세포모델

Humanized Mouse Models

Humanizad Mouse Models

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B-hCD94/hNKG2A/hNKG2C mice

Strain Name	C57BL/6-Klrd1^{tm1(KLRD1)Bcgen}Klrc1^{tm1(KLRC1)Bcgen}Klrc2^{tm1(KLRC2)Bcgen}/Bcgen	Common Name	B-hPVRIG/hTIGIT mice
Background	C57BL/6	Catalog number	112445
Aliases	KLRD1(CD94); KLRC1(NKG2A,CD159A); KLRC2(NKG2C,CD159C)

Protein expression analysis

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Strain specific CD94 expression analysis in heterozygous B-hCD94/hNKG2A/hNKG2C mice by flow cytometry. Splenocytes were collected from wild-type mice and heterozygous B-hCD94/hNKG2A/hNKG2C mice and stimulated with anti-CD3ε in vivo (7.5 μg/mice, stimulation for 24 hours, i.p. ), and analyzed by flow cytometry with species-specific anti-CD94 antibody. Human CD94 were exclusively detectable in heterozygous B-hCD94/hNKG2A/hNKG2C but not in wild-type mice.

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Strain specific NKG2A expression analysis in heterozygous B-hCD94/hNKG2A/hNKG2C mice by flow cytometry. Splenocytes were collected from wild-type mice and heterozygous B-hCD94/hNKG2A/hNKG2C mice and stimulated with anti-CD3ε in vivo (7.5 μg/mice, stimulation for 24 hours, i.p. ), and analyzed by flow cytometry with species-specific anti-NKG2A antibody. Human NKG2A were exclusively detectable in heterozygous B-hCD94/hNKG2A/hNKG2C but not in wild-type mice.

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Strain specific NKG2C expression analysis in heterozygous B-hCD94/hNKG2A/hNKG2C mice by flow cytometry. Splenocytes were collected from wild-type mice and heterozygous B-hCD94/hNKG2A/hNKG2C mice and stimulated with anti-CD3ε in vivo (7.5 μg/mice, stimulation for 24 hours, i.p. ), and analyzed by flow cytometry with species-specific anti-NKG2C antibody. Human NKG2C were exclusively detectable in heterozygous B-hCD94/hNKG2A/hNKG2C mice but not in wild-type mice.