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B-hCTLA4/hLAG3 mice
Strain Name
C57BL/6-Ctla4tm1(CTLA4)Bcgen Lag3tm1(LAG3)Bcgen/Bcgen
Common Name  B-hCTLA4/hLAG3 mice
Background C57BL/6 Catalog number  120529
Related Genes 
CTLA4 (Cytotoxic T-lymphocyte-associated protein 4,CD152);
LAG3
(lymphocyte-activation gene 3)
NCBI Gene ID
12477,16768

Protein expression analysis




Strain specific CTLA4 and LAG3 expression analysis in homozygous B-hCTLA4/hLAG3 mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hCTLA4/hLAG3 (H/H) mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-CTLA4 and anti-LAG3 antibody. Mouse CTLA4 was detectable in WT mice, mouse LAG3 was detectable in homozygous B-hCTLA4/hLAG3 and WT mice due to the anti-mouse LAG3 antibody cross-reacts with human LAG3. Human CTLA4 and LAG3 were exclusively detectable in homozygous B-hCTLA4/hLAG3 but not WT mice.