B-hICAM3 mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen, drug development, antibody discovery

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동물/세포 모델

동물/세포모델

Humanized Mouse Models

Humanizad Mouse Models

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B-hICAM3 mice

Strain Name	C57BL/6-Gt(ROSA)26^{tm1(ICAM3)Bcgen}/Bcgen	Common Name	B-hICAM3 mice
Background	C57BL/6N	Catalog number	111243
Aliases	CD50, CDW50, ICAM-R

Protein expression analysis of ICAM3 in T cells and B cells of splenocytes

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Strain specific ICAM3 expression analysis in homozygous B-hICAM3 mice by flow cytometry. T cells and B cells from spleen were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hICAM3 mice (H/H), and analyzed by flow cytometry with species-specific anti-ICAM3 antibody. Human ICAM3 was exclusively detectable in homozygous B-hICAM3 mice but not in wild-type mice.

Protein expression analysis of ICAM3 in NK cells, dendritic cells, granulocytes, monocytes and macrophages of splenocytes

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Strain specific ICAM3 expression analysis in homozygous B-hICAM3 mice by flow cytometry. NK cells, dendritic cells, granulocytes, monocytes, macrophages from spleen were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hICAM3 mice (H/H), and analyzed by flow cytometry with species-specific anti-ICAM3 antibody. Human ICAM3 was exclusively detectable in homozygous B-hICAM3 mice but not in wild-type mice.

Protein expression analysis of ICAM3 on T cells and B cells of blood

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Strain specific ICAM3 expression analysis in homozygous B-hICAM3 mice by flow cytometry. T cells and B cells from blood were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hICAM3 mice (H/H), and analyzed by flow cytometry with species-specific anti-ICAM3 antibody. Human ICAM3 was exclusively detectable in homozygous B-hICAM3 mice but not in wild-type mice.

Protein expression analysis of ICAM3 in NK cells, dendritic cells, granulocytes, monocytes and macrophages of blood

from clipboard

Strain specific ICAM3 expression analysis in homozygous B-hICAM3 mice by flow cytometry. NK cells, dendritic cells, granulocytes, monocytes, macrophages from blood were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hICAM3 mice (H/H), and analyzed by flow cytometry with species-specific anti-ICAM3 antibody. Human ICAM3 was exclusively detectable in homozygous B-hICAM3 mice but not in wild-type mice.