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B-hPD-1/hPD-L1/hIL2RA mice
Strain Name
C57BL/6-Pdcd1tm1(PDCD1)Bcgen Cd274tm1(CD274)Bcgen Cd25tm1(CD25)Bcgen/Bcgen
Common Name  B-hPD-1/hPD-L1/hIL2RA mice
Background C57BL/6 Catalog number  131078
Related Genes 
PD-1 (Programmed death-1) ;
  CD274 (CD274 antigen)
  CTLA4  (Cytotoxic T-lymphocyte-associated protein 4,CD152)
NCBI Gene ID
18566,60533,16184

Protein expression analysis in T cells


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Strain specific PD-1, PDL1 and IL2RA expression analysis in homozygous B-hPD-1/hPD-L1/hIL2RA mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hPD-1/hPD-L1/hIL2RA mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific PD-1, PD-L1 and IL2RA antibody. Mouse PD-1, PD-L1 and IL2RA were detectable in WT mice. Human PD-1, PD-L1 and IL2RA were exclusively detectable in homozygous B-hPD-1/hPD-L1/hIL2RA but not WT mice.

Protein expression analysis of IL2RA in Tregs

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Strain specific IL2RA expression analysis in homozygous B-hPD-1/hPD-L1/hIL2RA mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hPD-1/hPD-L1/hIL2RA mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific IL2RA antibody. Mouse IL2RA were detectable in WT mice. Human IL2RA were exclusively detectable in homozygous B-hPD-1/hPD-L1/hIL2RA but not WT mice.