B-hPDPN mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen, drug development, antibody discovery

Strain Name	C57BL/6N-Pdpn^{tm1(PDPN)Bcgen}/Bcgen	Common Name	B-hPDPN mice
Background	C57BL/6N	Catalog number	111099
Related Genes	AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A
NCBI Gene ID	14726

Protein expression analysis

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Strain specific PDPN expression analysis in homozygous B-hPDPN mice by western blot.
Lung tissue was collected from wild-type C57BL/6 mice (+/+) and homozygous B-hPDPN mice (H/H), and analyzed by western blot with anti-PDPN antibody. Mouse PDPN was only detectable in wild-type C57BL/6 mice. Human PDPN was only detectable in homozygous B-hPDPN mice but not in wild type mice.

mRNA expression analysis

Strain specific analysis of PDPN gene expression in wild-type C57BL/6 mice and B-hPDPN mice by RT-PCR. Mouse Pdpn mRNA was detectable in brain of wild-type C57BL/6 mice (+/+). Human PDPN mRNA was detectable only in homozygous B-hPDPN mice (H/H) but not in wild type mice.