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B-hHER3 mice
Strain Name
C57BL/6-Erbb3tm1(ERBB3)Bcgen/Bcgen
Common Name  B-hHER3 mice
Background C57BL/6 Catalog number 110791
Aliases

ERBB3, ErbB-3, FERLK, HER3, LCCS2, MDA-BF-1, VSCN1, c-erbB-3, c-erbB3, 

erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3 , erb-b2 receptor tyrosine kinase 3

mRNA expression analysis

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Strain specific analysis of HER3 gene expression in wild type (WT) mice and B-hHER3 mice by RT-PCR. Mouse Her3 mRNA was detectable only in liver of WT mice (+/+). Human HER3 mRNA was detectable only in homozygous B-hHER3 mice (H/H) but not in WT mice (+/+). 

IHC analysis of HER3 expression

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Immunohistochemical (IHC) analysis of HER3 expression in homozygous B-hHER3 mice. The liver and colon were collected from WT and homozygous B-hHER3 mice (H/H) and analyzed by IHC with anti-HER3 antibody. HER3 was detectable in WT mice and homozygous B-hHER3 mice due to the cross-reactivity of the antibody. The arrow indicates tissue cells with positive HER3 staining (brown).