Strain Name
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C57BL/6-NtrK3tm1(NTRK3)Bcgen/Bcgen
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Common Name
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B-hNTRK3 mice
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Background
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C57BL/6
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Catalog number
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111071
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Aliases
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NTRK3, GP145-TrkC, TRKC, gp145(trkC), neurotrophic receptor tyrosine kinase 3
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mRNA expression analysis
Strain specific analysis of NTRK3 gene expression in wild type (WT) mice and B-hNTRK3 mice by RT-PCR. Mouse Ntrk3 mRNA was detectable only in cerebellum of WT mice (+/+). Human NTRK3 mRNA was detectable only in homozygous B-hNTRK3 mice (H/H) but not in WT mice (+/+).
Protein expression analysis
Strain specific NTRK3 expression analysis in homozygous B-hNTRK3 mice by western blot. Brain, cerebellum, stomach, liver and colon were collected from wild type (WT) mice (+/+) and homozygous B-hNTRK3 mice (H/H), and analyzed by western blot with anti-NTRK3 antibody. NTRK3 was not detectable in liver of WT mice (+/+) and homozygous B-hNTRK3 mice (H/H). NTRK3 was detectable in brain, cerebellum, stomach and colon of WT mice (+/+) and homozygous B-hNTRK3 mice (H/H) due to the cross-reactivity of antibodies.