B-hTNFRSF11A mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen, drug development, antibody discovery

Please input keywords

Order

*Country

한국

미국

일본

중국

영국

호주

프랑스

독일

이탈리아

싱가포르

인도

러시아

캐나다

스위스

기타 국가

*Province

*City

*Name

*Telephone

*Company

*Position

*Email

*Verification code

*Verification Code

Home

동물/세포 모델

동물/세포모델

Humanized Mouse Models

Other Humanized Mice

Text

B-hTNFRSF11A mice

Strain Name

C57BL/6N-Tnfrsf11a^{tm1(TNFRSF11A)Bcgen}/Bcgen

Common Name

B-hTNFRSF11A mice

Background

C57BL/6N

Catalog number

112784

Aliases

CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7,

OSTS, PDB2, RANK, TRANCE-R, TRANCER

Description

RANKL binds to TNFRSF11A and induces the differentiation of osteoclast precursors into osteoclasts, promoting the activation of osteoclasts.
B-hTNFRSF11A mice used for myeloma and osteoporosis.

Protein expression analysis

from clipboard

Western blot analysis of TNFRSF11A protein expression in homozygous B-hTNFRSF11A mice. Various tissue lysates were collected from wild-type C57BL/6N mice (+/+) and homozygous B-hTNFRSF11A mice (H/H), and then analyzed by western blot with anti-TNFRSF11A antibody (abcam, ab182158). 40 μg total proteins were loaded for western blotting analysis. TNFRSF11A was detected in liver and stomach.

mRNA expression analysis

from clipboard

Strain specific analysis of TNFRSF11A mRNA expression in wild-type C57BL/6 mice and B-hTNFRSF11A mice by RT-PCR. Liver RNA were isolated from wild-type C57BL/6 mice (+/+) and homozygous B-hTNFRSF11A mice (H/H). Mouse Tnfrsf11a mRNA was detectable only in wild-type C57BL/6 mice. Human TNFRSF11A mRNA was detectable only in homozygous B-hTNFRSF11A mice but not in wild-type mice.