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B-hUPA mice
Strain Name

C57BL/6-Plautm1(PLAU)Bcgen/Bcgen

Common Name  B-hUPA mice
Background C57BL/6 Catalog number 111088
Aliases

ATF; QPD; UPA; URK; u-PA; BDPLT5

mRNA expression analysis

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Strain specific analysis of UPA gene expression in wild-type mice and B-hUPA mice by RT-PCR and western blot. (A) Mouse Upa mRNA was detectable in kidney of wild-type mice (+/+). Human UPA mRNA was detectable only in homozygous B-hUPA mice (H/H) but not in wild-type mice. (B) Liver and kidney tissues were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hUPA mice (H/H), and analyzed by western blot with anti-UPA antibody. UPA was detectable in wild-type C57BL/6 mice (+/+) and homozygous B-hUPA mice (H/H), as the antibody is crossly reactive with both human and mouse UPA.