BCG003 is a fully human monoclonal antibody targeting TNFR2, which was co-developed by Biocytogen and Dragon Boat Pharmaceutical. The preclinical results showed that BCG003 is an agonistic TNFR2 antibody without blocking the TNFα-TNFR2 interactions. BCG003 has a favorable anti-tumor activity in many syngeneic mouse tumor models. In addition, BCG003 can enhance the anti-tumor activity of immune checkpoint blockades in TNFR2 humanized mice with good safety profile.
1. Treatment with BCG003 reduced tumor volumes in multiple tumor models, including colon cancer, glioma, and melanoma models.
Figure 1. BCG003 showed anti-tumor activity in multiple tumor models.
2. Treatment of BCG003 enhanced the efficacy of PD-1/PD-L1 blockade in MC38 model
3. BCG003 is an IgG1 antibody with ADCC activity. In addition, BCG003 can enhance the CD8+ T cell proliferation. In vitro experiment showed that BCG003 treatment significantly increased the Teff/Treg ratio in tumor-microenvironment.
AACR 2022: 1C3, a Novel Non-blocking Anti-human TNFR2 Antibody Generated From RenMice, Exhibits Promising Anti-tumor Activity and Safety in Syngeneic Tumor Models in Humanized TNFR2 Mice