We identified TCR-mimic antibodies specific for KRAS G12V residues 7-16 complexed with HLA-A03 or HLA-A11. Both anti-KRAS G12V/HLA-A11 and anti-KRAS G12V/HLA-A03 antibodies showed abundant germline gene diversity and high affinity. Anti-KRAS G12V/HLA-A03 antibodies did not cross-bind HLA-A11 overexpressing cells loaded with KRAS mutant or wild-type peptides, or HLA-A03 overexpressing cells loaded with off-target peptides. The residue V6 of KRAS G12V was required for antibody binding according to the alanine scan assay. Cytotoxicity assays demonstrated specificity of the bispecific anti-KRAS G12V/HLA-A03 x CD3 T cell engager for KRAS G12V+/HLA-A0301+ cells.