B-MUP-uPA mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen, drug development, antibody discovery

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B-MUP-uPA mice

Strain Name	C57BL/6-Hipp1^{tm2(MUP-uPA)Bcgen}/Bcgen	Common Name	B-MUP-uPA mice
Background	C57BL/6	Catalog number	112036
Aliases	uPA; u-PA

Mouse uPA mRNA expression analysis by RT-qPCR

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uPA expression analysis in B-MUP-uPA mice by RT-qPCR. Liver and kidney tissues were collected from wild-type C57BL/6 mice (+/+) and heterozygous B-MUP-uPA mice (Mut/+) (n=3, female, 9-week-old). Mouse uPA was specific expression in the liver of heterozygous B-MUP-uPA mice and the level was higher than that in the wild-type.

ALT and AST concentrations in serum

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Serum ALT and AST analysis in B-MUP-uPA mice. Serum was collected from wild-type C57BL/6 mice (+/+) and heterozygous B-MUP-uPA mice (Mut/+) (n=10, male). Serum ALT and AST concentrations were normal in B-MUP-uPA mice at 3 weeks of age, but elevated and up to peek in 5 weeks. Indicating that occurs liver injury in B-MUP-uPA mice. (Data shows in Mean±SEM)

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Serum ALT and AST analysis in B-MUP-uPA mice. Serum was collected from wild-type C57BL/6 mice (+/+), heterozygous B-MUP-uPA mice (Mut/+) and homozygous B-MUP-uPA mice (Mut/Mut) (n=6, male). Serum uPA concentrations were normal in B-MUP-uPA mice at 4 weeks of age, but elevated and up to peek in 6 weeks. Indicating that occurs liver injury in B-MUP-uPA mice. (Data shows in Mean±SEM)