B-p53 KO rats_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen, drug development, antibody discovery

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B-p53 KO rats

Strain Name	SD-Trp53^tm1Bcgen/Bcgen	Common Name	B-p53 KO rats
Background	SD	Catalog number	210507
Aliases	Tp53, bbl, bfy, bhy, p4, p44, p5, p53

Project background

Tumor suppressor p53 encoded by Tp53 gene contributes to cell cycle arrest, apoptosis, senescence, DNA repair and metabolism. Homozygous Tp53 null rats display onset of spontaneous tumors at 4~6 months of age. B-p53-KO rats is a useful model for studying tumor formation, screening of in vivo carcinogenicity, and examining the efficacy of therapeutic agents.

Targeting strategy