Description

• Secretory leukocyte protease inhibitor (SLPI) possesses properties that combat inflammation and bacterial infection, while also facilitating the healing process of wounds. In pathological cases, SPLI is also highly expressed in many cancer cell lines, including ovarian, kidney, and colon cancers 
• The exons 1~3 of mouse Slpi gene that encode the full-length protein were replaced by human SLPI exons 1~4 in B-hSLPI mice. 
• Human SLPI was detectable in lung, liver and kidney of homozygous B-hSLPI mice.
• Mouse Slpi mRNA was detectable in lung of wild-type C57BL/6 mice. Human SLPI mRNA was detectable in B-hSLPI mice.
• This product is used for pharmacodynamics and safety evaluation of tumor diseases or anti-inflammatory effects.

mRNA expression analysis

Protein expression analysis

Western blot analysis of SLPI protein expression in wild-type mice and B-hSLPI mice. Various tissue lysates were collected from wild-type C57BL/6 (+/+) mice and homozygous B-hSLPI mice(H/H), and then analyzed by western blot with anti-SLPI antibody. 40 μg total proteins were loaded for western blotting analysis.