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B-hTLR3 mice
Strain Name C57BL/6N-Tlr3tm1(TLR3)Bcgen/Bcgen Common Name  B-hCLU mice
Background C57BL/6N Catalog number 111431
Aliases 

CD283, IIAE2, IMD83

Protein expression analysis

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Strain specific TLR3 expression analysis in homozygous B-hTLR3 mice by flow cytometry. Peritoneal washes and Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hTLR3 mice (H/H). Flow cytometry analysis of the Peritoneal washes-macrophages,Splenocytes-macrophages,DCs were analyzed with anti-TLR3 antibody. Mouse TLR3 was detected in Peritoneal washes-macrophages,Splenocytes-macrophages,DCs of wild-type mice. Human TLR3 was detected in Peritoneal washes-macrophages,Splenocytes-macrophages,DCs of homozygous B-hTLR3 mice. 

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Strain specific TLR3 expression analysis in homozygous B-hTLR3 mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hTLR3 mice (H/H). Flow cytometry analysis of the monocytes,granulocytes,NK cells were analyzed with anti-TLR3 antibody. Mouse TLR3 was detected in monocytes,granulocytes,NK cells of wild-type mice. Human TLR3 was detected in monocytes,NK cells of homozygous B-hTLR3 mice,but not in granulocytes. 

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Strain specific TLR3 expression analysis in homozygous B-hTLR3 mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hTLR3 mice (H/H). Flow cytometry analysis of the T cells and B cells were analyzed with anti-TLR3 antibody. Mouse TLR3 was detected in B cells of wild-type mice. Human TLR3 was detected in B cells of homozygous B-hTLR3 mice.