Strain Name
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C57BL/6N-Tlr3tm1(TLR3)Bcgen/Bcgen
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Common Name
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B-hCLU mice
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Background
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C57BL/6N
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Catalog number
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111431
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Aliases
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CD283, IIAE2, IMD83
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Protein expression analysis
Strain specific TLR3 expression analysis in homozygous B-hTLR3 mice by flow cytometry. Peritoneal washes and Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hTLR3 mice (H/H). Flow cytometry analysis of the Peritoneal washes-macrophages,Splenocytes-macrophages,DCs were analyzed with anti-TLR3 antibody. Mouse TLR3 was detected in Peritoneal washes-macrophages,Splenocytes-macrophages,DCs of wild-type mice. Human TLR3 was detected in Peritoneal washes-macrophages,Splenocytes-macrophages,DCs of homozygous B-hTLR3 mice.
Strain specific TLR3 expression analysis in homozygous B-hTLR3 mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hTLR3 mice (H/H). Flow cytometry analysis of the monocytes,granulocytes,NK cells were analyzed with anti-TLR3 antibody. Mouse TLR3 was detected in monocytes,granulocytes,NK cells of wild-type mice. Human TLR3 was detected in monocytes,NK cells of homozygous B-hTLR3 mice,but not in granulocytes.
Strain specific TLR3 expression analysis in homozygous B-hTLR3 mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hTLR3 mice (H/H). Flow cytometry analysis of the T cells and B cells were analyzed with anti-TLR3 antibody. Mouse TLR3 was detected in B cells of wild-type mice. Human TLR3 was detected in B cells of homozygous B-hTLR3 mice.