| Strain Name |
C57BL/6-Ranktm1(icre)Bcgen/Bcgen |
Stock No. |
110133 |
| Common name |
B-Rank-iCre mice
|
Gene symbol and name |
Tnfrsf11a, tumor necrosis factor receptor superfamily, member 11a |
| Strain of origin |
C57BL/6 |
Chromosome | 1 |
| Coat color | Black | Dietary information |
Growth and reproduction diet for experimental mice |
Results of agarose gel electrophoresis
Gel image of PCR products. PCR products are separated by gel electrophoresis on a 2% agarose gel. PC: samples used for PCR were collected from heterozygous mice; WT: samples used for PCR were collected from wild type mice; H2O: blank control.
Phenotype Analysis
Scheme for generating Wnt7bRANK mice. Rosa26-Wnt7b mice were generated and crossed with RANK-Cre mice (RANK-Cre was purchased from Biocytogen Co. Ltd., Beijing, China) to obtain Wnt7bRANK mice. Wnt7bRANK mice similar to the overexpression of Wnt7b in osteoblasts. the three-dimensional reconstruction of mCT scanning showed a significant increase in bone mass in both trabecular and cortical bone in Wnt7bRANK mice compared to their littermates (Rosa26Wnt7b,hereafter referred to as wildtype or WT).
(source: Wu F et al., 2021)
