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B-hCTLA4/h4-1BB mice
Strain Name
C57BL/6-Ctla4tm1(CTLA4)Bcgen Cd137tm1(CD137)Bcgen/Bcgen
Common Name  B-hCTLA4/h4-1BB mice
Background C57BL/6 Catalog number  120539
Related Genes 
CTLA4 (Cytotoxic T-lymphocyte-associated protein 4,CD152)
TNFRSF9 (Tumor necrosis factor receptor superfamily, member 9)
NCBI Gene ID
12477,21942

Protein expression analysis


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Strain specific 4-1BB expression analysis in homozygous B-hCTLA4/h4-1BB mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hCTLA4/h4-1BB (H/H) mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-h4-1BB antibody. Mouse 4-1BB was detectable in WT mice but not homozygous B-hCTLA4/h4-1BB mice. Human 4-1BB was exclusively detectable in homozygous B-hCTLA4/h4-1BB mice but not WT mice.


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Strain specific CTLA4 expression analysis in homozygous B-hCTLA4/h4-1BB mice by flow cytometry. 

Splenocytes were collected from WT and homozygous B-hCTLA4/h4-1BB (H/H) mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-hCTLA4 antibody. Mouse CTLA4 was detectable in WT mice but not homozygous B-hCTLA4/h4-1BB mice. Human CTLA4 was exclusively detectable in homozygous B-hCTLA4/h4-1BB mice but not WT mice.