B-Fabp4-iCre mice

C57BL/6N-Fabp4tm1(icre)Bcgen/Bcgen • 110152

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B-Fabp4-iCre mice

Product nameB-Fabp4-iCre mice
Catalog number110152
Strain nameC57BL/6N-Fabp4tm1(icre)Bcgen/Bcgen
Strain backgroundC57BL/6N
NCBI gene ID11770 (Mouse)
Official symbolfatty acid binding protein 4
Chromosome2
AliasesAp2; P15; ALBP; Lbpl; AFABP; 422/aP2; ALBP/Ap2
ApplicationB-Fabp4-iCre mice may be useful for Cre-loxP studies of adipocytes.
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  • Description
  • Targeting strategy
  • Phenotypic analysis

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      Description

      Homozygous knockout mice are viable and fertile. Compared to wild-type mice, FABP4-deficient mice exhibit increased susceptibility to diet-induced obesity.

      Gene editing strategy
      Phenotype Analysis
      Scheme for generating RhebADKO mice.The RhebFL/FLmice were crossed with Fabp4-Cremice (Fabp4-Cre micewere purchased from Biocytogen Co.Ltd., Beijing, China) to obtain RhebADKO mice. Rheb was not detected in the interscapular BAT, inguinal and epididymal WAT of RhebADKO mice. Compared to control mice, the interscapular BAT pads of RhebADKO mice were significantly lighter and smaller, while no significant differences were observed in the inguinal and epididymal WAT.
      Instructions of genomic DNA extraction

      chematic representation of the toe clipping.