B-NDG hB2M/HLA-A3.1 mice

NOD.CB17-PrkdcscidIl2rgtm1BcgenB2mtm1(B2M/HLA-A3.1)Bcgen/Bcgen • 112450

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B-NDG hB2M/HLA-A3.1 mice

Product nameB-NDG hB2M/HLA-A3.1 mice
Catalog number112450
Strain nameNOD.CB17-PrkdcscidIl2rgtm1BcgenB2mtm1(B2M/HLA-A3.1)Bcgen/Bcgen
Strain backgroundB-NDG
NCBI gene ID19090,16186,12010 (Human)
Aliasesp460; scid; slip; DNAPK; DNPK1; HYRC1; XRCC7; dxnph; DOXNPH; DNAPDcs; DNA-PKcs; gc; p64; [g]c; CD132; gamma(c); Ly-m11; beta2m; beta2-m
ApplicationTo verify the efficacy of HLA-A3.1 restricted vaccines and antibody-based therapies；Promote the development of human CD8+ T cells
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  • Phenotypic analysis

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      Protein expression analysis
      B2M and HLA-A3.1 expression analysis in homozygous B-NDG hB2M/HLA-A3.1 mice by flow cytometry. Splenocytes were collected from B-NDG mice (+/+) and homozygous B-NDG hB2M/HLA-A3.1 mice (H/H), and analyzed by flow cytometry with strain specific antibodies. Mouse B2M was detectable in B-NDG mice but not in B-NDG hB2M/HLA-A3.1 mice. Human B2M and HLA-A3 were exclusively detectable in homozygous B-NDG hB2M/HLA-A3.1 mice but not in B-NDG mice.
      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-NDG hB2M/HLA-A3.1 mice] (Cat# 112450) was purchased from Biocytogen.