B-NDG hB2M/HLA-A24.2 mice

NOD.CB17-PrkdcscidIl2rgtm1BcgenB2mtm1(B2M/HLA-A24.2)Bcgen/Bcgen • 112560

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B-NDG hB2M/HLA-A24.2 mice

Product nameB-NDG hB2M/HLA-A24.2 mice
Catalog number112560
Strain nameNOD.CB17-PrkdcscidIl2rgtm1BcgenB2mtm1(B2M/HLA-A24.2)Bcgen/Bcgen
Strain backgroundB-NDG
NCBI gene ID19090,16186,12010 (Human)
Aliasesp460; scid; slip; DNAPK; DNPK1; HYRC1; XRCC7; dxnph; DOXNPH; DNAPDcs; DNA-PKcs; gc; p64; [g]c; CD132; gamma(c); Ly-m11; beta2m; beta2-m
ApplicationTo verify the efficacy of HLA-A24.2 restricted vaccines and antibody-based therapies；Promote the development of human CD8+ T cells
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  • Phenotypic analysis

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      Protein expression analysis

      B2M and HLA-A expression analysis in homozygous B-NDG hB2M/HLA-A24.2 mice by flow cytometry. Splenocytes were collected from B-NDG mice (+/+) and homozygous B-NDG hB2M/HLA-A24.2 mice (H/H), and analyzed by flow cytometry with strain specific antibodies. Mouse B2M was detectable in B-NDG mice but not in B-NDG hB2M/HLA-A24.2 mice. Human B2M and HLA-A were exclusively detectable in homozygous B-NDG hB2M/HLA-A24.2 mice but not in B-NDG mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-NDG hB2M/HLA-A24.2 mice] (Cat# 112560) was purchased from Biocytogen.