Join us at the 7th Tumor Models for Immuno-Oncology Summit in San Francisco, CA from January 24 - 26, 2023! We will be presenting "Next-Generation Mouse Models to Evaluate Efficacy of Novel Antibody and Cell-Based Immunotherapies" at 10:15AM PST on Thursday, Jan. 26.
Speaker Session: Thursday, Jan. 26, 10:15AM PST
Speaker: Jenna Frame, Ph.D. Manager, Scientific Communications & Marketing, Biocytogen Boston
Topic: Next-Generation Mouse Models to Evaluate Efficacy of Novel Antibody and Cell-Based Immunotherapies
• Introduce the use and advantages of humanized mouse models for evaluating preclinical efficacy, toxicity, and other mechanisms of action of antibody/biologic combination therapies
• Outline the use of cell lines expressing tumor-associated antigens to evaluate dual checkpoint and TAA blockade in immune-checkpoint humanized mice
• Describe the applicability of highly immunodeficient (B-NDG) mice and second- generation B-NDG models with humanized cytokines for evaluating antibody and cell-based immunotherapies
