The immunodeficient B-NDG mice (NOD.CB17-Prkdcscid IL2rgtm1Bcgen) was independently designed and generated by Biocytogen. B-NDG mice were generated by deleting the Il2g gene from NOD scid mice with severe immunodeficient phenotype. This mouse model lacks mature T cells, B cells and functional NK cells. It is internationally recognized as an immunodeficient mouse model well suited for human-derived tissue or cell engraftment.
The immunodeficient B-NDG mouse model (NOD-Prkdcscid IL2rgtm1/Bcgen) was independently designed and generated by Biocytogen. B-NDG mice are generated by deleting the IL2rg gene from NOD-scid mice (NSG mice) with severe immunodeficiency phenotype. Lacking mature T cells, B cells or functional NK cells, and displaying cytokine signaling deficiencies, this mouse model has the highest degree of immunodeficiency and thus is most suitable for engraft and growth of human hematopoietic stem cells (HSCs), peripheral blood mononuclear cells (PBMCs) and human tumor cells or tissues.
Learn more about the B-NDG mice applications and case studies, please download the brochure.
