B-hCTLA4/hTIGIT mice

C57BL/6-Ctla4tm1(CTLA4)Bcgen Tigittm1(TIGIT)Bcgen/Bcgen • 111860

B-hCTLA4/hTIGIT mice

Product nameB-hCTLA4/hTIGIT mice
Catalog number111860
Strain nameC57BL/6-Ctla4tm1(CTLA4)Bcgen Tigittm1(TIGIT)Bcgen/Bcgen
Strain backgroundC57BL/6
NCBI gene ID1493,201633 (Human)
AliasesALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12; VSIG9; VSTM3; WUCAM; IDDM12; VSIG9

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  • Phenotypic analysis

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    출판물

      Protein expression analysis

      Strain specific CTLA4 and TIGIT expression analysis in homozygous B-hCTLA4/hTIGIT mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+;+/+) and homozygous B-hCTLA4/hTIGIT mice (H/H;H/H), and analyzed by flow cytometry with species-specific anti-CTLA4 antibody and anti-TIGIT antibody. Mouse CTLA4 and TIGIT were detectable in wild-type mice. Human CTLA4 and TIGIT were exclusively detectable in homozygous B-hCTLA4hTIGIT mice but not in wild-type mice.

      Strain specific CTLA4 and TIGIT expression analysis in homozygous B-hCTLA4/hTIGIT mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+;+/+) and homozygous B-hCTLA4/hTIGIT mice (H/H;H/H) stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-CTLA4 antibody and anti-TIGIT antibody. Mouse CTLA4 and TIGIT were detectable in wild-type mice. Human CTLA4 and TIGIT were exclusively detectable in homozygous B-hCTLA4/hTIGIT mice but not in wild-type mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hCTLA4/hTIGIT mice] (Cat# 111860) was purchased from Biocytogen.