C57BL/6-Ctla4tm1(CTLA4)Bcgen Tigittm1(TIGIT)Bcgen/Bcgen • 111860
| Product name | B-hCTLA4/hTIGIT mice |
|---|---|
| Catalog number | 111860 |
| Strain name | C57BL/6-Ctla4tm1(CTLA4)Bcgen Tigittm1(TIGIT)Bcgen/Bcgen |
| Strain background | C57BL/6 |
| NCBI gene ID | 1493,201633 (Human) |
| Aliases | ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12; VSIG9, VSTM3, WUCAM |
Protein expression analysis
Strain specific CTLA4 and TIGIT expression analysis in homozygous B-hCTLA4/hTIGIT mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+;+/+) and homozygous B-hCTLA4/hTIGIT mice (H/H;H/H), and analyzed by flow cytometry with species-specific anti-CTLA4 antibody and anti-TIGIT antibody. Mouse CTLA4 and TIGIT were detectable in wild-type mice. Human CTLA4 and TIGIT were exclusively detectable in homozygous B-hCTLA4hTIGIT mice but not in wild-type mice.
Strain specific CTLA4 and TIGIT expression analysis in homozygous B-hCTLA4/hTIGIT mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+;+/+) and homozygous B-hCTLA4/hTIGIT mice (H/H;H/H) stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-CTLA4 antibody and anti-TIGIT antibody. Mouse CTLA4 and TIGIT were detectable in wild-type mice. Human CTLA4 and TIGIT were exclusively detectable in homozygous B-hCTLA4/hTIGIT mice but not in wild-type mice.
