B-hCXCL7/hCXCL4 mice

C57BL/6N-Ppbptm1(PPBP)Bcgen Pf4tm1(PF4)Bcgen/Bcgen • 112063

제품 주문
B-hCXCL7 mice
B-hCXCR2 mice

B-hCXCL7/hCXCL4 mice

Product nameB-hCXCL7/hCXCL4 mice
Catalog number112063
Strain nameC57BL/6N-Ppbptm1(PPBP)Bcgen Pf4tm1(PF4)Bcgen/Bcgen
Strain backgroundC57BL/6N
NCBI gene ID5473,5196 (Human)
AliasesB-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1; CXCL4, PF-4, SCYB4
제품 주문

이 페이지에서

  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hCXCL7/hCXCL4 mice. The exons 1-3 of mouse Cxcl7 gene that encode the full-length protein and the exons 1-3 of mouse Cxcl4 gene that encode the full-length protein including the non-coding region between Cxcl7 gene and Cxcl4 gene were replaced by human CXCL7 exons 1-3 and human CXCL4 exons 1-3 in B-hCXCL7/hCXCL4 mice.

      Protein expression analysis
      Strain specific CXCL7 expression analysis in homozygous B-hCXCL7/hCXCL4 mice by ELISA. Serum was collected from wild-type mice (+/+) and homozygous B-hCXCL7/hCXCL4 mice (H/H), and analyzed by ELISA with species-specific CXCL7 ELISA kit. Mouse CXCL7 was detectable in wild-type mice. Human CXCL7 was exclusively detectable in homozygous B-hCXCL7/hCXCL4 mice but not in wild-type mice.
      Strain specific CXCL4 expression analysis in homozygous B-hCXCL7/hCXCL4 mice by ELISA. Serum was collected from wild-type mice (+/+) and homozygous B-hCXCL7/hCXCL4 mice (H/H), and analyzed by ELISA with species-specific CXCL4 ELISA kit. Mouse CXCL4 was detectable in wild-type mice. Human CXCL4 was exclusively detectable in homozygous B-hCXCL7/hCXCL4 mice but not in wild-type mice.