B-hCD3EDG/hCD19 ad/hCD20 mice

C57BL/6-Cd3etm2(CD3E)Bcgen Cd3dtm1(CD3D)Bcgen Cd3gtm1(CD3G)Bcgen Cd19tm7(CD19)Bcgen Ms4a1tm2(MS4A1)Bcgen/Bcgen • 115148

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B-hCD3EDG/hCD19 ad/hCD20 mice

Catalog Number: 115148
Strain Name: C57BL/6-Cd3etm2(CD3E)Bcgen Cd3dtm1(CD3D)Bcgen Cd3gtm1(CD3G)Bcgen Cd19tm7(CD19)Bcgen Ms4a1tm2(MS4A1)Bcgen/Bcgen
Strain Background: C57BL/6
NCBI gene ID: 916,915,917,930,931 (Human)
Aliases: CD3epsilon, IMD18, T3E, TCRE; CD3-DELTA, CD3DELTA, IMD19, T3D; CD3-GAMMA, CD3GAMMA, IMD17, T3G; B4, CVID3; B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7
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B-hCD3EDG/hCD19 ad/hCD20 mice

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  • Description
  • Phenotypic analysis

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      Description

      Gene Information:

      •  CD3: Encoded by CD3E, D, G; part of the Ig superfamily. It forms the essential signaling backbone of the T-cell receptor (TCR) complex. CD20: Encoded by the MS4A1 gene, CD20 is a non-glycosylated transmembrane phosphoprotein and a member of the membrane-spanning 4-domains subfamily A (MS4A) family. It plays an important role in B-cell activation, proliferation, and calcium signaling..

      Protein Expression:

      • CD3: Constitutive and universal marker for all mature T cells (CD4+, CD8+). Always present on the cell surface. CD20: CD20 is expressed predominantly on B-lineage cells, from the late pre-B-cell stage through mature and memory B cells. Its expression is generally absent on early B-cell precursors and terminally differentiated plasma cells.
      CD3E Expression in Spleen

      Mouse and human CD3E expression analysis in splenocytes. Splenocytes were collected from wild-type C57BL/6JNifdc mice and B-hCD3EDG/hCD19 ad/hCD20 mice. CD3E expression was analyzed by flow cytometry using anti-mouse CD3E antibody (Biolegend, 100210) and anti-human CD3E antibody (Biolegend, 317344).

      CD3E Expression in Blood

      Mouse and human CD3E expression analysis in blood. Blood was collected from wild-type C57BL/6JNifdc mice and B-hCD3EDG/hCD19 ad/hCD20 mice. CD3E expression was analyzed by flow cytometry using anti-mouse CD3E antibody (Biolegend, 100210) and anti-human CD3E antibody (Biolegend, 317344).

      CD19 Expression in Spleen

      Mouse and human CD19 expression analysis in splenocytes.Splenocytes were collected from wild-type C57BL/6JNifdc mice and B-hCD3EDG/hCD19 ad/hCD20 mice. CD19 expression was analyzed by flow cytometry using anti-mouse CD19 antibody (Biolegend, 115507) and anti-human CD19 antibody (Biolegend, 302234).

      CD19 Expression in Blood

      Mouse and human CD19 expression analysis in blood. Bloodwas collected from wild-type C57BL/6JNifdc mice and B-hCD3EDG/hCD19 ad/hCD20 mice. CD19 expression was analyzed by flow cytometry using anti-mouse CD19 antibody (Biolegend, 115507) and anti-human CD19 antibody (Biolegend, 302234).

      CD20 Expression in Spleen

      Mouse and human CD20 expression analysis in splenocytes. Splenocytes were collected from wild-type C57BL/6JNifdc mice and B-hCD3EDG/hCD19 ad/hCD20 mice. CD20 expression was analyzed by flow cytometry using anti-mouse CD20 antibody (Biolegend, 152108) and anti-human CD20 antibody (Biolegend, 302306).

      CD20 Expression in Blood

      Mouse and human CD20 expression analysis in blood. Bloodwas collected from wild-type C57BL/6JNifdc mice and B-hCD3EDG/hCD19 ad/hCD20 mice. CD20 expression was analyzed by flow cytometry using anti-mouse CD20 antibody  (Biolegend,152108) and anti-human CD20 antibody (Biolegend,  302306).

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hCD3EDG/hCD19 ad/hCD20 mice] (Cat# 115148) was purchased from Biocytogen.