B-hNCR3 mice(CB-17 SCID)

CB17/lcr-PrkdcscidIgs2tm1(NCR3)Bcgen/Bcgen • 112931

B-hNCR3 mice(CB-17 SCID)

Product nameB-hNCR3 mice(CB-17 SCID)
Catalog number112931
Strain nameCB17/lcr-PrkdcscidIgs2tm1(NCR3)Bcgen/Bcgen
Strain backgroundCB-17 SCID
NCBI gene ID259197 (Human)
Aliases1C7, MALS, CD337, LY117, NKp30

이 페이지에서

  • Targeting strategy
  • Phenotypic analysis

포스터

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    출판물

      Targeting Strategy

      Gene targeting strategy for B-hNCR3 mice(CB-17 SCID). The full coding sequences of human NCR3 gene, including the promoter, 5’UTR and 3’UTR are inserted into mouse Hipp11 (H11) locus in B-hNCR3 mice(CB-17 SCID).

      Protein expression analysis in blood

      Strain specific NCR3 expression analysis with blood from homozygous B-hNCR3 mice(CB-17 SCID) by flow cytometry. Blood cells were collected from wild-type CB-17 SCID mice (+/+) and homozygous B-hNCR3 mice(CB-17 SCID) (H/H), and analyzed by flow cytometry with species-specific anti-human NCR3 antibody (Biolegend, 325208). Human NCR3 was exclusively detectable in homozygous B-hNCR3 mice(CB-17 SCID).

      Protein expression analysis in spleen

      Strain specific NCR3 expression analysis with splenocytes from homozygous B-hNCR3 mice(CB-17 SCID) by flow cytometry. Splenocytes were collected from wild-type CB-17 SCID mice (+/+) and homozygous B-hNCR3 mice(CB-17 SCID) (H/H), and analyzed by flow cytometry with species-specific anti-human NCR3 antibody (Biolegend, 325208). Human NCR3 was exclusively detectable in homozygous B-hNCR3 mice(CB-17 SCID).