Description
Homozygousmiceforthetargetedmutationareviable,fertile,normalinsizeanddonotdisplayanygrossphysicalorbehavioralabnormalities
Analysis of liver by immunofluorescence(IF).
Control: without tamoxifen treatment; HNF4α: a regulator of liver-specific gene expression. Immunofluorescence for HNF4α, tdTomato, and DAPI on liver sections shows Alb-iCreERT2(Mut/+), CAG-LSL-tdTomato(Mut/+) mice labeled almost all hepatocytes after tamoxifen treatment.
Analysis of kidney by immunofluorescence(IF).
Control: without tamoxifen treatment; HNF4α: a regulator of liver-specific gene expression. Immunofluorescencefor HNF4α, tdTomato, and DAPI on kidney sections shows Alb-iCreERT2(Mut/+), CAG-LSL-tdTomato(Mut/+) mice were not labeled after tamoxifen treatment.
* When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-Alb-iCreERT2 mice] (Cat# 110137) was purchased from Biocytogen.
